Which city is home to the University of Illinois?

The University of Illinois is located in Champaign, Illinois, making this answer correct. Champaign is part of the Urbana-Champaign metropolitan area, which houses the main campus of the University of Illinois. This university is known for its research programs, diverse range of academic offerings, and vibrant campus life, contributing significantly to the local economy and culture.

The other cities listed do not host the University of Illinois. Minneapolis is known for the University of Minnesota, Detroit has Wayne State University and the University of Detroit Mercy, and Lincoln is home to the University of Nebraska-Lincoln. Each of these cities has its own respective higher education institutions, emphasizing the geographic diversity of universities across the United States.